Daily Archives: July 19, 2017

Now I’m Really Mad

at Social Security.  I found my original application and saw where they took down the names of my kids.  The guy I called Monday tried to tell me that I never told them I had children.  I’m going to get my senator’s office involved to see if we can expedite this a little bit.  I want it taken care of as soon as possible.

Not much else going on around here.  I’m just trying to stay busy and not worry about my writing right now.  I’m not sure what’s wrong but I’m not interested in trying to work on my thesis or on anything to get ready for my fiction class.  I wrote one small bit for  a  contest and I like it.  But I’m worried that all I can do are small bits.  I don’t know what the problem is.

But I am staying with the blogging so that will be good.  What I’m really struggling with is the scope of my thesis. Do I want to confine it to just before I was diagnosed to present?  Or do I want to include the episodes in my early life as well?  I feel like they are important but don’t know how to cover it in depth.  But I have time to figure it out.


Underlying molecular mechanism of bipolar disorder revealed

This is an interesting article! Bipolar disorder has always been thought to be a genetic disorder, that is due to mutations in genes. One of the reasons bring it is inherited and runs in families. However, here the authors make a case for it not being genetic but physiological in nature. I’ve put the most important passage in the article in quotes below. If you’d love to read the whole article, there’s, as always, a link below too. CRMP2 is a protein that is involved in neural networking, i.e in arranging neurons from soma to axon and making networks between neurons. In bipolar disorder, the activity of this protein is low. When Lithium is given to Lithium responsive neurons, the activity of CRMP2 is brought back up to normal, thereby correcting the underlying cause of the disorder. That’s what the authors say. Just have to wait and see if this is truly the underlying cause of bipolar disorder. 

“In hiPS cells created from lithium-responsive and non-responsive patients, researchers observed a physiological difference in the regulation of CRMP2, which rendered the protein to be in a much more inactive state in responsive patients. However, the research showed that when lithium was administered to these cells, their regulatory mechanisms were corrected, restoring normal activity of CRMP2 and correcting the underlying cause of their disorder. Thus, the study demonstrated that bipolar disorder can be rooted in physiological—not necessarily genetic—mechanisms. The insights derived from the hiPS cells were validated in actual brain specimens from patients with bipolar disorder (on and off lithium), in animal models, and in the actions of living neurons.”