Daily Archives: September 9, 2015

The PTSD Highway

  Freewriting Exercise at the 2015 Catamaran Writing Conference’s Creative Nonfiction Workshop As my husband Craig drives our daughters on Highway One in a rented cobalt blue Nissan Pathfinder, I spot the Holman Highway exit. My stomach drops, then sours. … Continue reading

Prevention

This week is suicide prevention week, and I have some thoughts on the issue, so why not write about it?...

Awareness overload

exclamationThis issue first started bothering me shortly after I escaped from my domestic violence situation. Before that, I barely paid attention to all the awareness events. October rolled around, and I discovered that domestic violence awareness was the same month as breast cancer awareness. I have a few friends that have been affected by breast cancer, so I am in no way minimizing this important issue; but I was mad. “That’s not fair! Something very important to me is now overshadowed by something else I’m supposed to care about!” Of course the guilt set in after that…how could I be so callous?

The second time this bothered me was last year when I volunteered in a hospital gift shop. A woman came in for an awareness bracelet, and started complaining that her particular problem only had a very putrid-looking greenish-gray bracelet (I can’t even remember what her illness was). She became very upset about how all the other illnesses had pretty colors, why did hers have to be so ugly. Oh come on, people. This is getting out of hand.

An article titled “What Good is ‘Raising Awareness?’” in The Atlantic, states:

According to a commentary published this month in the American Journal of Public Health, the United States has almost 200 official “health awareness days.” (The U.S. Department of Health and Human Services lists all national health observances on its website.*) And that’s not counting all the unofficial ones, sponsored by organizations.

A New York Times article, “Awareness is Overrated,” comes to the conclusion:

But the funny part about all of this awareness-raising is that it doesn’t accomplish all that much.

There are only 12 months, 52 weeks, and 365 days (except Leap Year), every year. Some health issues, tragic events, or causes are going to be left out or overshadowed. Then throw in all the current events with hashtags in social media, and curmudgeons like me just want to throw our arms up in the air and yell “Enough already!”

Here’s a novel idea…how about if we become aware of the human beings around us and the struggles that everyone goes through, and try to show compassion to everyone we meet? After all, do we really know what’s going on behind that smile or those tears?


*I started to type out all of those awareness days, but just go to the website if you’re really interested…I don’t have all day!

Tagged: awareness, compassion

Gofundme Fire Damage Update

There was a big write up in the local paper about the fire at my mom’s. An excerpt (link to full article on gofundme update page.)

brandi fireBrandi Harris fights back tears as she talks with friends on the front porch of her home on North Fayette Street in Jacksonville. Dirt, ashes and fresh scratches cover her hands, reminders of her effort to save pets from her house after a fire early Tuesday. More than half a dozen pets died from smoke inhalation and several more are missing.

 

They were also interviewed by a local tv station today, though I’ve not seen any footage posted yet.

The article teaser was about the police officer who had to seek hospital treatment for smoke inhalation. I was impressed with the way they kept it focused on my sister and brother in law’s efforts to save their pets, though, rather than playing up the overloaded power strip causing the fire. Even my fundme page was mentioned in the article, though there’s been little activity on it. Speaks to the charitable nature of this place.

The death of the kitty at the vet’s office brought the total up to nine cats and two ferrets,plus all her pet frogs. Rocky is still fighting and sis says she is going to keep him since he’s fought this hard and they’ve invested so much money in his vet care. Long as he’s loved, excellent.

My nephew has been beating himself up because it was his room, his power strip, that started the whole thing. Less than worry about property damage considering he lost all his stuff, he feels responsible for the death of all the cats.

I went to the fire department today and got two brand new smoke detectors. I don’t trust the ones that came with this place, not after seven years. So everyone- check your smoke detectors, the batteries, even if your landlord is responsible. And hope they work better than the ones the landlord installed at mom’s. No way it should take flames leaping out before smoke is detected.

Thanks to everyone passing this on, to those who have donated, to all those wishing my family well. It is greatly appreciated.

P.S.- The cats listed as “missing” in the article have all been found and are being housed by a relative, in great shape.

May the lost pets rest in peace and know they will not be forgotten.

 


The Land of Irritation or Depleted or Something Else

You bug me.  Yes, you.  Whoever you are.  If you're reading this, you bug me.  And so does everyone who's not reading this.

Right now almost everyone and everything irritates me.  A lot.  And I don't know why.

I'm severely limiting my social interactions, digitally and in real life.  Because I can't keep up the facade.

I can't pretend the things you're saying or doing or wearing or eating aren't making me crazy.  It takes so much energy to be polite and smile when I really just want to go off on a diatribe about how ridiculous I find you.

I absolutely know how self-centered this sounds (because it is).  I understand how un-Christlike this sounds (because it is).  I get it.  And in my heart of hearts I don't feel this way.

But in my nerves I do.  I don't want to.  I'm working on it.  But right now I do.

And my isolation is for both of us.

I'm certain my facade will eventually break down when we're together, and I'll tell you how whiny I think you are.  I'll tell you to quit complaining and either do something about it or just shut up.  Which will hurt you.

Which will hurt me.  Because I will feel your hurt and carry the weight of that in my heart and on my back.  And I just don't have that strength right now.

I think part of the reason everyone and everything is bothering me is because I feel like it's my job to fix all the problems.  All of them.  All of them in the world.

I know it's not.  In my head.  But in my heart I feel differently.  Accountable.  Responsible.  At fault.

And I want the world perfect.  I want the world to be the way I want it.  That includes the people and their behavior.  And if I'm accountable, at fault, then it's my job to fix it.

But it isn't.  And people get very irritated when I try.  (As well they should.)

So I'm just going to pull back and give myself some space to get through this.  It's kind of like taking my ball and going home because you won't play what I want to play, only a bit more mature (I hope).  You can keep the ball.  I'm just going home.

The Land of Irritation or Depleted or Something Else

You bug me.  Yes, you.  Whoever you are.  If you're reading this, you bug me.  And so does everyone who's not reading this.

Right now almost everyone and everything irritates me.  A lot.  And I don't know why.

I'm severely limiting my social interactions, digitally and in real life.  Because I can't keep up the facade.

I can't pretend the things you're saying or doing or wearing or eating aren't making me crazy.  It takes so much energy to be polite and smile when I really just want to go off on a diatribe about how ridiculous I find you.

I absolutely know how self-centered this sounds (because it is).  I understand how un-Christlike this sounds (because it is).  I get it.  And in my heart of hearts I don't feel this way.

But in my nerves I do.  I don't want to.  I'm working on it.  But right now I do.

And my isolation is for both of us.

I'm certain my facade will eventually break down when we're together, and I'll tell you how whiny I think you are.  I'll tell you to quit complaining and either do something about it or just shut up.  Which will hurt you.

Which will hurt me.  Because I will feel your hurt and carry the weight of that in my heart and on my back.  And I just don't have that strength right now.

I think part of the reason everyone and everything is bothering me is because I feel like it's my job to fix all the problems.  All of them.  All of them in the world.

I know it's not.  In my head.  But in my heart I feel differently.  Accountable.  Responsible.  At fault.

And I want the world perfect.  I want the world to be the way I want it.  That includes the people and their behavior.  And if I'm accountable, at fault, then it's my job to fix it.

But it isn't.  And people get very irritated when I try.  (As well they should.)

So I'm just going to pull back and give myself some space to get through this.  It's kind of like taking my ball and going home because you won't play what I want to play, only a bit more mature (I hope).  You can keep the ball.  I'm just going home.

The Land of Irritation or Depleted or Something Else

You bug me.  Yes, you.  Whoever you are.  If you're reading this, you bug me.  And so does everyone who's not reading this.

Right now almost everyone and everything irritates me.  A lot.  And I don't know why.

I'm severely limiting my social interactions, digitally and in real life.  Because I can't keep up the facade.

I can't pretend the things you're saying or doing or wearing or eating aren't making me crazy.  It takes so much energy to be polite and smile when I really just want to go off on a diatribe about how ridiculous I find you.

I absolutely know how self-centered this sounds (because it is).  I understand how un-Christlike this sounds (because it is).  I get it.  And in my heart of hearts I don't feel this way.

But in my nerves I do.  I don't want to.  I'm working on it.  But right now I do.

And my isolation is for both of us.

I'm certain my facade will eventually break down when we're together, and I'll tell you how whiny I think you are.  I'll tell you to quit complaining and either do something about it or just shut up.  Which will hurt you.

Which will hurt me.  Because I will feel your hurt and carry the weight of that in my heart and on my back.  And I just don't have that strength right now.

I think part of the reason everyone and everything is bothering me is because I feel like it's my job to fix all the problems.  All of them.  All of them in the world.

I know it's not.  In my head.  But in my heart I feel differently.  Accountable.  Responsible.  At fault.

And I want the world perfect.  I want the world to be the way I want it.  That includes the people and their behavior.  And if I'm accountable, at fault, then it's my job to fix it.

But it isn't.  And people get very irritated when I try.  (As well they should.)

So I'm just going to pull back and give myself some space to get through this.  It's kind of like taking my ball and going home because you won't play what I want to play, only a bit more mature (I hope).  You can keep the ball.  I'm just going home.

The Land of Irritation or Depleted or Something Else

You bug me.  Yes, you.  Whoever you are.  If you're reading this, you bug me.  And so does everyone who's not reading this.

Right now almost everyone and everything irritates me.  A lot.  And I don't know why.

I'm severely limiting my social interactions, digitally and in real life.  Because I can't keep up the facade.

I can't pretend the things you're saying or doing or wearing or eating aren't making me crazy.  It takes so much energy to be polite and smile when I really just want to go off on a diatribe about how ridiculous I find you.

I absolutely know how self-centered this sounds (because it is).  I understand how un-Christlike this sounds (because it is).  I get it.  And in my heart of hearts I don't feel this way.

But in my nerves I do.  I don't want to.  I'm working on it.  But right now I do.

And my isolation is for both of us.

I'm certain my facade will eventually break down when we're together, and I'll tell you how whiny I think you are.  I'll tell you to quit complaining and either do something about it or just shut up.  Which will hurt you.

Which will hurt me.  Because I will feel your hurt and carry the weight of that in my heart and on my back.  And I just don't have that strength right now.

I think part of the reason everyone and everything is bothering me is because I feel like it's my job to fix all the problems.  All of them.  All of them in the world.

I know it's not.  In my head.  But in my heart I feel differently.  Accountable.  Responsible.  At fault.

And I want the world perfect.  I want the world to be the way I want it.  That includes the people and their behavior.  And if I'm accountable, at fault, then it's my job to fix it.

But it isn't.  And people get very irritated when I try.  (As well they should.)

So I'm just going to pull back and give myself some space to get through this.  It's kind of like taking my ball and going home because you won't play what I want to play, only a bit more mature (I hope).  You can keep the ball.  I'm just going home.

Fibroblast growth factor 9 is a novel modulator of negative affect (depression)

This study used rats and postmortem human hippocampal tissue to show that there are two proteins in inverse relationships to each other that are involved in major depressive disorder (MDD). They are both fibroblast growth factors (FGF) specifically FGF2 and FGF9. FGF2 is decreased (http://www.ncbi.nlm.nih.gov/pubmed/25079902) in postmortem tissue of depressed individuals and FGF9 in increased. Also in rats, the same thing is seen. In rats if FGF9 levels are increased experimentally, they start showing symptoms of depression, and localized blockade of FGF9 reduces depression and anxiety symptoms. Also, “chronic social defeat stress” (an animal model recapitulating some aspects of MDD) in rats increases FGF9 levels.

What are FGF2 and 9? They are growth factors, produced by the cells of the body and the brain. They are involved in the proliferation and differentiation of somatic cells and neurons. They are important and key factors in the growth, differentiation and development of the brain. (The regulation of FGFs expression as well as of their receptors during development presumably plays a critical role in cell-cell signaling among neurons, astrocytes and microglia in the immature human brain: http://www.med.unibs.it/~airc/pdf/fgf%20human%20brain.pdf)

Important in the growth and development and differentiation of the brain, changed in depression, changed when depression is induced, and in normal controls, levels are different than in people with MDD. All good reasons to think of them as good targets for treatment and as markers for MDD.

Original Article: http://www.pnas.org/content/early/2015/09/02/1510456112

Fibroblast growth factor 9 is a novel modulator of negative affect

Molecular mechanisms mediating negative emotion and contributing to major depression remain elusive: here, we present evidence implicating fibroblast growth factor 9 (FGF9) as a key mediator. We use whole-transcriptome studies of postmortem human tissue to demonstrate that FGF9 is elevated in depression. Reverse translation animal studies demonstrate that both endogenous and exogenous FGF9 promotes anxiety- and depression-like behavior. Conversely, localized blockade of endogenous FGF9 expression decreases anxiety behavior. To our knowledge, this paper is the first description of hippocampal FGF9 function and the first evidence implicating FGF9 in negative affect. Thus, FGF9 represents a novel target for treating affective disorders. Moreover, our findings suggest that FGF2 and FGF9 work in functional opposition; we hypothesize that the balance between FGF factors may prove critical for optimal regulation of mood.

Abstract

Both gene expression profiling in postmortem human brain and studies using animal models have implicated the fibroblast growth factor (FGF) family in affect regulation and suggest a potential role in the pathophysiology of major depressive disorder (MDD). FGF2, the most widely characterized family member, is down-regulated in the depressed brain and plays a protective role in rodent models of affective disorders. By contrast, using three microarray analyses followed by quantitative RT-PCR confirmation, we show that FGF9 expression is up-regulated in the hippocampus of individuals with MDD, and that FGF9 expression is inversely related to the expression of FGF2. Because little is known about FGF9’s function in emotion regulation, we used animal models to shed light on its potential role in affective function. We found that chronic social defeat stress, an animal model recapitulating some aspects of MDD, leads to a significant increase in hippocampal FGF9 expression, paralleling the elevations seen in postmortem human brain tissue. Chronic intracerebroventricular administration of FGF9 increased both anxiety- and depression-like behaviors. In contrast, knocking down FGF9 expression in the dentate gyrus of the hippocampus using a lentiviral vector produced a decrease in FGF9 expression and ameliorated anxiety-like behavior. Collectively, these results suggest that high levels of hippocampal FGF9 play an important role in the development or expression of mood and anxiety disorders. We propose that the relative levels of FGF9 in relation to other members of the FGF family may prove key to understanding vulnerability or resilience in affective disorders.


TA-DA – Our new badges to support mental health in South Africa

Oooooh! Look what our lovely Blahpolar designed for us! :)

We’ve got badges for Africa!

1440168933090 1440168622159 1440169843437 1440169719398 1440169089098 Ooh la la!

Comment on this post and we’ll send you the code so that you can stick it on your blog/ website. And you know what, feel free to put it on your Facebook page too. Let’s create a network of people who take mental health seriously in South Africa. Let’s share our knowledge, our stories, our jokes and most importantly our different forms of hope to save a life.

Because being mentally ill isn’t a fashion statement.

-OLE Team