Daily Archives: June 6, 2016
Here is a list of top five of ways to beat the summertime blues! Avoid Swimming, anywhere, beach or pool, family friends or strangers! Avoid BBQs! Eating too much, drinking too much, avoid it all! Avoid Bonfires! Staying up late can get you down! Avoid Dating! (s)he may want to go to any of the […]
These guys are SOOOOOO tasty. Jesus. Fucking. God Almighty! Ahhh….love it. *giggles* Ladies…enjoy😉
Ready. Set. Sail! Ohhhhhhh…….I just learned a secret. A pretty dark secret. A deep. Dark. Secret. Ha!!! Oh God! I thought it was all in my head. Well my husband has been keeping a dirty little secret from me for…let’s see…maybe our ENTIRE MARRIAGE!!! And he just told me yesterday. Yup. I wish I was… More His Dirty Little Secret
So the older daughter is working Vacation Bible School and the younger one is attending Switch Week, which is kind of VBS for older children. Waiting for them to get home.
Finished cleaning out the laundry room–I threw away so many unmatched socks. They were everywhere. But it’s all ready to be painted next week so I am looking forward to that. Finally getting rid of this green color that was all over the house when we bought it. Painting the kitchen, kids’s den, laundry, and half-bath.
I really made myself tired today. Im not used to doing so much a one time. I think maybe I need to slow down the rest of the day.
I think I will lie down for a little while. Then see if anyone else has posted in our classs for the summer. See if I did it right or wrong. Have a great week, everybody!
Mood I still dealt with anxiety last week, but nothing compared to the one prior. I was able to enjoy the long Memorial Day weekend, and pretty much the rest of the week, with just a few panic like moments that I was able to deal with by breathing and meditation. I am frustrated with […]
Although I am not at all unresponsive to medication, I would love to try this technique of deep brain stimulation (DBS) to see if it would repair/heal/rejuvenate the brain structures that are thought to be responsible for bipolar disorder. In this study, it is thought the cingulum bundle (which is a fiber tract in the brain called that connects different parts of the gray matter in the frontal area of the brain) may not be “strong” as in normal people. The brain’s frontal area is involved in decision making and problem solving and is smaller in people with bipolar disorder (BPD). So strengthening the connections in the frontal cortex of the brain should have a beneficial effect on people with bipolar disorder. This study is being done to see if DBS will help people who have BPD.
Many patients are often unresponsive to medications
CLEVELAND — Jennifer Sweet, MD, a neurosurgeon at University Hospitals Case Medical Center, recently opened a clinical research study to learn if there is a structural target in the brain for patients suffering from bipolar disorder and whether deep brain stimulation (DBS) can bring them relief.
Participants are being recruited through the UH Mood Disorders Program, which treats about 1,000 patients annually with bipolar disorder.
Bipolar disorder is associated with episodes of mood swings ranging from depressive lows to manic highs. Each of these cycles can last for weeks or months. It is among the leading causes of disability in young adults worldwide, according to Dr. Sweet, who is also an Assistant Professor of Neurosurgery at Case Western Reserve University School of Medicine.
While many patients respond to medications, most do not have complete control of cycling, and others have little or no response. It is hoped that DBS can help such non-responsive patients, or perhaps down the line even patients whose response to drugs become less effective over time.
Dr. Sweet’s study has two parts that will continue for at least three years. In the first part, currently underway and continuing through this year, she actively is enrolling 10 bipolar type I patients who do not respond to medications, 10 bipolar type I patients who do respond to treatment, and 10 healthy volunteers.
Participants will get a specialized type of MRI with diffusion-weighted imaging sequences, which can see how water molecules spread through the brain to create three dimensional maps of neurons in their brains. Dr. Sweet and her team will look for “connectivity” differences in structures among the different groups of participants.
“There are no obvious structural abnormalities in bipolar patients that can be seen with conventional MRI, but perhaps we can show that while Point A is still connected to Point B in bipolar patients, this connection or wiring is not functioning properly. Maybe the ‘cables’ aren’t as strong as in healthy controls,” said Dr. Sweet.
The biologic cables she refers to compose a fiber tract in the brain call the cingulum bundle that connects different parts of the gray matter in the frontal area of the brain.
According to the National Institute of Mental Health Web site, one MRI study found that the brain’s frontal area in adults with bipolar disorder tends to be smaller and function less well compared to adults without bipolar disorder. This area of the brain is involved in “executive” functions such as solving problems and making decisions.
Pinpointing differences in the structure of the cables may give neurosurgeons a new target for treating the disorder through DBS.
Once the first part of the study is complete, Dr. Sweet’s group will then recruit six of the bipolar participants who are unresponsive to medications and in whom structural imaging showed abnormal connectivity, to undergo a randomized, double-blinded pilot study to evaluate the safety and efficacy of DBS.
The participants will undergo DBS surgery, researchers and participants will both be blinded to the state of the stimulator. Prior to, during, and after the study, patients will be provided routine clinical and research care by the UH Mood Disorders Program.
“Bipolar disorder is so debilitating for many of the people who have it, and it strikes at a younger age, so it is a disease with which patients must contend throughout their lives. If DBS works, it will offer hope for patients, especially those who get no relief from medications,” said Dr. Sweet.
The study is currently funded by the National Institutes of Health to the Case Western Reserve University School of Medicine.
Deep brain stimulation (DBS) has been approved by the FDA for treating the symptoms of Parkinson’s disease and essential tremor, and it is FDA approved under the Humanitarian Device Exemption for the treatment of dystonia and obsessive-compulsive disorder. Researchers also are exploring whether DBS can help improve life for patients with other disorders, such as unipolar depression, bipolar depression, and memory loss, among other diseases.
My first post ever, the one with which I started Bipolar1Blog!
The purpose of these posts about bipolar d/o is not to get sympathy for myself, or to shock anyone. It is simply to describe what it feels like to have bipolar disorder. The purpose of all this is to inform and hopefully destigmatize mental illness. I’m hoping that if I talk about my experiences, then all of you will see that this can happen to anyone. Hopefully reading about my experiences will also help people identify mental illness, perhaps in themselves or others and get help. Also, as I talk about my mental illness, I am seeing that it frees others to talk about their illnesses. And what a relief it is to be able to talk to each other, instead of hiding and cowering in shame because we have an illness. There should be no shame associated with any illness, we did not choose to have this illness…
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